Endocrine Abstracts

Introduction: Increased hepatic de novo lipogenesis (DNL) is often associated with greater intrahepatic triglyceride (IHTG) content and/or decreased insulin sensitivity; however, the contribution of DNL to each has not been fully elucidated. Therefore, the present work determined if increased DNL, achieved via adoption of an isocaloric high-sugar diet, resulted in concomitant increases in IHTG content and/or decreases in insulin sensitivity.Methods: Sixt...

Background: Intrahepatic triglyceride (IHTG) accumulation, a cardiometabolic disease risk factor, is greater in individuals consuming saturated-fat (SFA) compared to polyunsaturated-fat (PUFA) enriched diets. We have demonstrated that compared to SFA, PUFA are preferentially partitioned into oxidation pathways, which may, in part, explain the divergence in IHTG accumulation. However, it remains unclear if this preferential handling is maintained when hepatocel...

Background: Fasting hyperglycaemia and hypertriglyceridemia are characteristic of insulin resistance (IR), type 2 diabetes, and non-alcoholic fatty liver disease, but the underlying mechanisms remain unclear. Rodent work has suggested this is due to selective hepatic IR; defined by increased hepatic gluconeogenesis (GNG) and de novo lipogenesis (DNL). The aim of this study was to determine if signatures of selective hepatic IR were associated with hyp...